Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting

Introduction. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-w...

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Bibliographic Details
Published in:Canadian respiratory journal 2023-05, Vol.2023, p.3302405-8
Main Authors: Komura, Moegi, Sato, Tadashi, Suzuki, Yohei, Yoshikawa, Hitomi, Nitta, Naoko Arano, Hayashi, Mika, Kuwasaki, Eriko, Horikoshi, Kimiko, Nishioki, Toshihiko, Mori, Mikiko, Kodama, Yuzo, Sasaki, Shinichi, Takahashi, Kazuhisa
Format: Article
Language:English
Subjects:
Analysis
Asthma
Biological markers
Biomarkers
Blood
Body mass index
Chronic obstructive pulmonary disease
Complications and side effects
Disease Progression
Eosinophilia
Eosinophils
Glaucoma
Health aspects
Hospitals
Humans
Hyperplasia
Leukocyte Count
Lung
Lung diseases
Lung diseases, Obstructive
Medical records
Medical research
Medicine, Experimental
Observational studies
Oxygen therapy
Patients
Physiological aspects
Pneumonia
Pulmonary Disease, Chronic Obstructive
Respiratory therapy
Risk factors
Spirometry
Steroids
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Description
Summary:Introduction. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-world data of COPD patients to assess the risk factors of COPD exacerbation focusing on blood eosinophils. Materials and Methods. Patients with COPD who visited our hospital between January 1, 2018, and December 31, 2018, were recruited, and their background information, spirometry data, laboratory test results, and moderate-to-severe exacerbation events during the one-year follow-up period were collected from the electronic medical records and analyzed. The COPD exacerbation risk factors were assessed using univariate and multivariate logistic regression analyses. Results. Twenty-two of 271 (8.1%) patients experienced moderate-to-severe exacerbation. Patients with exacerbation showed worse pulmonary function, and we found that a high blood eosinophil count (≥350 cells/μL; p=0.014), low % FEV1 (
ISSN:1198-2241
1916-7245
DOI:10.1155/2023/3302405