Cell surface engineering and application in cell delivery to heart diseases

Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and expandability, cells have become a...

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Bibliographic Details
Published in:Journal of biological engineering 2018-12, Vol.12 (1), p.28-28, Article 28
Main Authors: Lee, Daniel Y, Cha, Byung-Hyun, Jung, Minjin, Kim, Angela S, Bull, David A, Won, Young-Wook
Format: Article
Language:English
Subjects:
Antigens
Bone marrow
Cancer
Cancer immunotherapy
cardiac diseases
cardiac repair
Cardiovascular diseases
Care and treatment
cell modification
Cell surface
Cell surface engineering
cell therapy
Chemotaxis
Coronary artery disease
Cytokines
Genetic engineering
Genetic modification
Growth factors
Heart attacks
Heart diseases
Homing
Hydrophobicity
Hypoxia
Immunotherapy
Insertion
Leukemia
Lymphocytes
Medical innovations
Medicine
Mesenchymal stem cells
Methods
Organic chemistry
Reagents
Regenerative medicine
Retention
Review
Stem cells
Tissue engineering
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Summary:Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and expandability, cells have become an attractive reagent for advanced therapeutic strategies. Therefore, the ability to modify cells and manipulate their functions according to intended therapeutic designs has been the central scientific interest in the field of biomedical research. Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. Alternatively, many endeavors have been made to develop surface engineering techniques that can circumvent the limitations of genetic modification. In this review, current methods of non-genetic cell surface modification, including chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, will be introduced. Moreover, cell surface engineering plausible for cardiac remodeling and the future prospective will be discussed at the end.
ISSN:1754-1611
1754-1611
DOI:10.1186/s13036-018-0123-6