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Cell surface engineering and application in cell delivery to heart diseases
Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and expandability, cells have become a...
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| Published in: | Journal of biological engineering 2018-12, Vol.12 (1), p.28-28, Article 28 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c638t-c2bae0ba9c92d315d3db276cc561040c3164dc101692d728202d4f38f46a333 |
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| container_end_page | 28 |
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| container_start_page | 28 |
| container_title | Journal of biological engineering |
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| creator | Lee, Daniel Y Cha, Byung-Hyun Jung, Minjin Kim, Angela S Bull, David A Won, Young-Wook |
| description | Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and
expandability, cells have become an attractive reagent for advanced therapeutic strategies. Therefore, the ability to modify cells and manipulate their functions according to intended therapeutic designs has been the central scientific interest in the field of biomedical research. Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. Alternatively, many endeavors have been made to develop surface engineering techniques that can circumvent the limitations of genetic modification. In this review, current methods of non-genetic cell surface modification, including chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, will be introduced. Moreover, cell surface engineering plausible for cardiac remodeling and the future prospective will be discussed at the end. |
| doi_str_mv | 10.1186/s13036-018-0123-6 |
| format | article |
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expandability, cells have become an attractive reagent for advanced therapeutic strategies. Therefore, the ability to modify cells and manipulate their functions according to intended therapeutic designs has been the central scientific interest in the field of biomedical research. Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. Alternatively, many endeavors have been made to develop surface engineering techniques that can circumvent the limitations of genetic modification. In this review, current methods of non-genetic cell surface modification, including chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, will be introduced. Moreover, cell surface engineering plausible for cardiac remodeling and the future prospective will be discussed at the end.</description><identifier>ISSN: 1754-1611</identifier><identifier>EISSN: 1754-1611</identifier><identifier>DOI: 10.1186/s13036-018-0123-6</identifier><identifier>PMID: 30524502</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Antigens ; Bone marrow ; Cancer ; Cancer immunotherapy ; cardiac diseases ; cardiac repair ; Cardiovascular diseases ; Care and treatment ; cell modification ; Cell surface ; Cell surface engineering ; cell therapy ; Chemotaxis ; Coronary artery disease ; Cytokines ; Genetic engineering ; Genetic modification ; Growth factors ; Heart attacks ; Heart diseases ; Homing ; Hydrophobicity ; Hypoxia ; Immunotherapy ; Insertion ; Leukemia ; Lymphocytes ; Medical innovations ; Medicine ; Mesenchymal stem cells ; Methods ; Organic chemistry ; Reagents ; Regenerative medicine ; Retention ; Review ; Stem cells ; Tissue engineering</subject><ispartof>Journal of biological engineering, 2018-12, Vol.12 (1), p.28-28, Article 28</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c638t-c2bae0ba9c92d315d3db276cc561040c3164dc101692d728202d4f38f46a333</citedby><cites>FETCH-LOGICAL-c638t-c2bae0ba9c92d315d3db276cc561040c3164dc101692d728202d4f38f46a333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278044/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2158149237?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30524502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Daniel Y</creatorcontrib><creatorcontrib>Cha, Byung-Hyun</creatorcontrib><creatorcontrib>Jung, Minjin</creatorcontrib><creatorcontrib>Kim, Angela S</creatorcontrib><creatorcontrib>Bull, David A</creatorcontrib><creatorcontrib>Won, Young-Wook</creatorcontrib><title>Cell surface engineering and application in cell delivery to heart diseases</title><title>Journal of biological engineering</title><addtitle>J Biol Eng</addtitle><description>Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and
expandability, cells have become an attractive reagent for advanced therapeutic strategies. Therefore, the ability to modify cells and manipulate their functions according to intended therapeutic designs has been the central scientific interest in the field of biomedical research. Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. Alternatively, many endeavors have been made to develop surface engineering techniques that can circumvent the limitations of genetic modification. In this review, current methods of non-genetic cell surface modification, including chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, will be introduced. Moreover, cell surface engineering plausible for cardiac remodeling and the future prospective will be discussed at the end.</description><subject>Antigens</subject><subject>Bone marrow</subject><subject>Cancer</subject><subject>Cancer immunotherapy</subject><subject>cardiac diseases</subject><subject>cardiac repair</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>cell modification</subject><subject>Cell surface</subject><subject>Cell surface engineering</subject><subject>cell therapy</subject><subject>Chemotaxis</subject><subject>Coronary artery disease</subject><subject>Cytokines</subject><subject>Genetic engineering</subject><subject>Genetic modification</subject><subject>Growth factors</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Homing</subject><subject>Hydrophobicity</subject><subject>Hypoxia</subject><subject>Immunotherapy</subject><subject>Insertion</subject><subject>Leukemia</subject><subject>Lymphocytes</subject><subject>Medical innovations</subject><subject>Medicine</subject><subject>Mesenchymal stem cells</subject><subject>Methods</subject><subject>Organic chemistry</subject><subject>Reagents</subject><subject>Regenerative medicine</subject><subject>Retention</subject><subject>Review</subject><subject>Stem cells</subject><subject>Tissue 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| subjects | Antigens Bone marrow Cancer Cancer immunotherapy cardiac diseases cardiac repair Cardiovascular diseases Care and treatment cell modification Cell surface Cell surface engineering cell therapy Chemotaxis Coronary artery disease Cytokines Genetic engineering Genetic modification Growth factors Heart attacks Heart diseases Homing Hydrophobicity Hypoxia Immunotherapy Insertion Leukemia Lymphocytes Medical innovations Medicine Mesenchymal stem cells Methods Organic chemistry Reagents Regenerative medicine Retention Review Stem cells Tissue engineering |
| title | Cell surface engineering and application in cell delivery to heart diseases |
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