Scientific and clinical implications of genetic and cellular heterogeneity in uveal melanoma

Here, we discuss the presence and roles of heterogeneity in the development of uveal melanoma. Both genetic and cellular heterogeneity are considered, as their presence became undeniable due to single cell approaches that have recently been used in uveal melanoma analysis. However, the presence of p...

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Bibliographic Details
Published in:Molecular biomedicine 2021-08, Vol.2 (1), p.25-25, Article 25
Main Authors: de Lange, Mark J., Nell, Rogier J., van der Velden, Pieter A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cancer
Cloning
Driver mutation
Genotype & phenotype
Heterogeneity
Immune infiltrate
Melanoma
Molecular Medicine
Mutation
Precursor lesion
Review
Stem cells
Tumors
Uveal melanoma
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Summary:Here, we discuss the presence and roles of heterogeneity in the development of uveal melanoma. Both genetic and cellular heterogeneity are considered, as their presence became undeniable due to single cell approaches that have recently been used in uveal melanoma analysis. However, the presence of precursor clones and immune infiltrate in uveal melanoma have been described as being part of the tumour already decades ago. Since uveal melanoma grow in the corpus vitreous, they present a unique tumour model because every cell present in the tumour tissue is actually part of the tumour and possibly plays a role. For an effective treatment of uveal melanoma metastasis, it should be clear whether precursor clones and normal cells play an active role in progression and metastasis. We propagate analysis of bulk tissue that allows analysis of tumour heterogeneity in a clinical setting.
ISSN:2662-8651
2662-8651
DOI:10.1186/s43556-021-00048-x