Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry

Current models in biological psychiatry focus on a handful of model species, and the majority of work relies on data generated in rodents. However, in the same sense that a comparative approach to neuroanatomy allows for the identification of patterns of brain organization, the inclusion of other sp...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2015-09, Vol.9, p.233-233
Main Authors: Maximino, Caio, Silva, Rhayra Xavier do Carmo, da Silva, Suéllen de Nazaré Santos, Rodrigues, Laís do Socorro Dos Santos, Barbosa, Hellen, de Carvalho, Tayana Silva, Leão, Luana Ketlen Dos Reis, Lima, Monica Gomes, Oliveira, Karen Renata Matos, Herculano, Anderson Manoel
Format: Article
Language:English
Subjects:
Anamniotes
Anatomy
Archives & records
Behavior
behavioral models
Biological Psychiatry
Brain architecture
Brain research
Epistemology
Gene expression
Genetics
Hypotheses
Insects
Invertebrates
Life sciences
Mental disorders
Nervous system
Neuroscience
Neurosciences
Organisms
Physiology
Psychiatry
Psychological aspects
Psychopathology
Sauropsida
Species
teleost fish
Validity
Zebrafish
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Summary:Current models in biological psychiatry focus on a handful of model species, and the majority of work relies on data generated in rodents. However, in the same sense that a comparative approach to neuroanatomy allows for the identification of patterns of brain organization, the inclusion of other species and an adoption of comparative viewpoints in behavioral neuroscience could also lead to increases in knowledge relevant to biological psychiatry. Specifically, this approach could help to identify conserved features of brain structure and behavior, as well as to understand how variation in gene expression or developmental trajectories relates to variation in brain and behavior pertinent to psychiatric disorders. To achieve this goal, the current focus on mammalian species must be expanded to include other species, including non-mammalian taxa. In this article, we review behavioral neuroscientific experiments in non-mammalian species, including traditional "model organisms" (zebrafish and Drosophila) as well as in other species which can be used as "reference." The application of these domains in biological psychiatry and their translational relevance is considered.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2015.00233