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Functional outcomes and survival of patients with oral and oropharyngeal cancer after total glossectomy

Cancer of the oral cavity and oropharynx presents aggressive behavior and its diagnosis is, in most cases, performed in advanced stages. Total glossectomy is a therapeutic option in locally advanced cancer, and the only one in the recurrent or residual disease, after chemoradiotherapy. To evaluate t...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2020-09, Vol.86 (5), p.545-551
Main Authors: Quinsan, Isabela de Cássia Marins, Costa, Gustavo Carvalho, Priante, Antonio Vitor Martins, Cardoso, Cesar Augusto, Nunes, Caio Lúcio Soubhia
Format: Article
Language:English
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Summary:Cancer of the oral cavity and oropharynx presents aggressive behavior and its diagnosis is, in most cases, performed in advanced stages. Total glossectomy is a therapeutic option in locally advanced cancer, and the only one in the recurrent or residual disease, after chemoradiotherapy. To evaluate the clinical-epidemiological profile, postoperative complications, survival rates and functional aspects of patients with oral cavity and oropharynx cancer after total glossectomy. It was a retrospective study where 22 patients were included with oral cavity and oropharyngeal cancer after total glossectomy at the Hospital Regional do Vale do Paraíba, em Taubaté, São Paulo. All patients were male, with a median age of 57 years, most of tumors are located in the tongue and floor of the mouth and classified as stage IVa. Total glossectomy as initial treatment was performed in 18 and as salvage in four patients. The major pectoralis myocutaneous flap was used for reconstruction in all cases. The main postoperative complication was wound infection and salivary fistula. Overall survival was 19% and cancer-specific survival was 30.8% in five years. Eight patients were rehabilitated for exclusive oral feeding without the dependence tracheostomy and enteral tube, all with an overall survival greater than 15 months. O câncer da cavidade oral e da orofaringe apresenta comportamento agressivo e seu diagnóstico é, na maioria dos casos, realizado em fases avançadas. A glossectomia total é uma opção terapêutica no câncer localmente avançado e a única no resgate de pacientes com doença residual ou recorrente, após a quimiorradioterapia. Avaliar o perfil clínico-epidemiológico, as complicações pós-operatórias, as taxas de sobrevida e os aspectos funcionais de pacientes com câncer da cavidade oral e da orofaringe submetidos à glossectomia total no Hospital Regional do Vale do Paraíba, em Taubaté, São Paulo. Estudo retrospectivo em que foram incluídos 22 pacientes com câncer de cavidade oral e orofaringe submetidos à glossectomia total. Todos os pacientes eram do gênero masculino, com mediana de 57 anos, com tumores principalmente na língua e no assoalho da boca e classificados, em sua maioria, como estádio clínico IVa. A glossectomia total como tratamento inicial foi realizada em 18 e como resgate em quatro pacientes. O retalho miocutâneo peitoral maior foi utilizado para a reconstrução em todos os casos. A principal complicação pós-operatória foi a infecção da ferida operatória e
ISSN:1808-8694
1808-8686
1808-8686
DOI:10.1016/j.bjorl.2019.02.005