Hormone-Glutamine Metabolism: A Critical Regulatory Axis in Endocrine-Related Cancers

The endocrine-related cancers and hormones are undoubtedly highly interconnected. How hormones support or repress tumor induction and progression has been extensively profiled. Furthermore, advances in understanding the role of glutamine metabolism in mediating tumorigenesis and development, coupled...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (17), p.10086
Main Authors: Xu, Fengyuan, Shi, Jialu, Qin, Xueyun, Zheng, Zimeng, Chen, Min, Lin, Zhi, Ye, Jiangfeng, Li, Mingqing
Format: Article
Language:English
Subjects:
androgen
Breast cancer
estrogen
Estrogens
Glutamine
hormone
Hormones
Insulin
Lipids
Ovarian cancer
Progesterone
prostaglandin
Review
Thyroid
Tumorigenesis
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Summary:The endocrine-related cancers and hormones are undoubtedly highly interconnected. How hormones support or repress tumor induction and progression has been extensively profiled. Furthermore, advances in understanding the role of glutamine metabolism in mediating tumorigenesis and development, coupled with these in-depth studies on hormone (e.g., estrogen, progesterone, androgen, prostaglandin, thyroid hormone, and insulin) regulation of glutamine metabolism, have led us to think about the relationship between these three factors, which remains to be elucidated. Accordingly, in this review, we present an updated overview of glutamine metabolism traits and its influence on endocrine oncology, as well as its upstream hormonal regulation. More importantly, this hormone/glutamine metabolism axis may help in the discovery of novel therapeutic strategies for endocrine-related cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231710086