Design of a customized multipurpose nano-enabled implantable system for in-vivo theranostics

• Published in: Sensors (Basel, Switzerland) Switzerland), 2014-10, Vol.14 (10), p.19275-19306
• Main Authors: Juanola-Feliu, Esteve, Miribel-Català, Pere Ll, Páez Avilés, Cristina, Colomer-Farrarons, Jordi, González-Piñero, Manel, Samitier, Josep
• Format: Article
• Language: English
• Subjects: Biocompatibility; biocompatible; Biocompatible Materials; Bioengineering; BIOMEDICAL DEVICES; Biomedical materials; Biosensing Techniques; biosensor; Biosensors; biotelemetry; Customization; Customizing; Devices; ELECTRODE ARRAYS; Electrònica biomèdica; Enginyeria biomèdica; FUEL-CELL; GLUCOSE; HEALTH-CARE; Humans; implantable multi-sensor; In vivo tests; innovation; KET; Medical devices; Medical equipment; Medical technology; nanomedicine; Nanotechnology; Patients; personalized medicine; Physiology; Prostheses and Implants; Quality of life; REAL-TIME; SENSOR; Sensors; Surgical implants; Technological innovations; WEARABLE DEVICES; Wireless networks; WIRELESS POWER TRANSFER; Àrees temàtiques de la UPC
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s141019275

The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs) could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device.