EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features

The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC sample...

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Bibliographic Details
Published in:Brazilian oral research 2024-01, Vol.38, p.e018
Main Authors: Noronha, Mariana Saturnino de, Viana, Karolina Skarlet Silva, Aguiar, Maria Cássia Ferreira de, Squarize, Cristiane Helena, Abreu, Mauro Henrique Nogueira Guimarães de, Mendonça, Elismauro Francisco, Bernardes, Vanessa de Fátima
Format: Article
Language:English
Subjects:
Adenoma, Pleomorphic
Carcinoma, Adenoid Cystic
Cell Cycle
Cell Proliferation
DENTISTRY, ORAL SURGERY & MEDICINE
Enhancer of Zeste Homolog 2 Protein
Humans
Immunohistochemistry
Salivary Gland Neoplasms
Short Communication
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Summary:The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy.
ISSN:1806-8324
1807-3107
1807-3107
DOI:10.1590/1807-3107bor-2024.vol38.0018