Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA

ANCA (anti-neutrophil cytoplasmic antibody) vasculitides are systemic autoimmune diseases in which anti-neutrophilic cytoplasmic antibodies activate primed neutrophils, thereby generating an inflammatory cascade resulting in the damage of small sized blood vessels in various organs of the body, incl...

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Bibliographic Details
Published in:Case reports in nephrology 2019, Vol.2019 (2019), p.1-5
Main Authors: Rust, Harlan, Kowalewska, Jolanta, Rana, Amna Z., Vanga, Amaresh
Format: Article
Language:English
Subjects:
Biopsy
Blood
Case Report
Case reports
Cellular biology
Disease
Dyspnea
Family medical history
Heart
Immunoglobulins
Laboratories
Microscopy
Neutrophils
Pathology
Proteins
Stains & staining
Triglycerides
Urine
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Summary:ANCA (anti-neutrophil cytoplasmic antibody) vasculitides are systemic autoimmune diseases in which anti-neutrophilic cytoplasmic antibodies activate primed neutrophils, thereby generating an inflammatory cascade resulting in the damage of small sized blood vessels in various organs of the body, including the heart. Pleuropericardial involvement is underrecognized as a complication of ANCA vasculitis and is highlighted in this case report of a 51-year-old male who presented with an initial symptomatic presentation of pleuropericardial effusion progressing to pericardial tamponade in the setting of a later renal biopsy proven pauci-immune crescentic glomerulonephritis with high ANA titres along with positive cANCA (cytoplasmic ANCA) and PR3 (proteinase 3) antibodies. He was found to have acute renal failure which progressively got better with cyclophosphamide.
ISSN:2090-6641
2090-665X
DOI:10.1155/2019/4983139