Natural Products: Insights into Leishmaniasis Inflammatory Response

Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous me...

Full description

Saved in:
Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.420-431-439
Main Authors: Vermelho, Alane Beatriz, Silva, Jefferson Rocha de A., Amaral, Ana Claudia F., Alves, Renan L., Cardoso, Verônica, Mazotto, Ana Maria, Rodrigues, Igor A., Pinheiro, Anderson S.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Antineoplastic Agents - chemistry
Biological Products - chemistry
Cell Communication
Chemotherapy
Cytokines
Cytokines - metabolism
Drug Design
Epidemiology
Health aspects
Host-bacteria relationships
Humans
Infections
Inflammation
Leishmania
Leishmaniasis
Leishmaniasis - immunology
Leukotriene B4 - chemistry
Natural products
Observations
Parasites
Parasitic diseases
Physiological aspects
Plant Extracts - chemistry
Review
Zoonoses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous membranes, and internal organs. Despite the relevance of host inflammatory mediators on parasite burden control, Leishmania and host immune cells interaction may generate an exacerbated proinflammatory response that plays an important role in the development of leishmaniasis clinical manifestations. Plant-derived natural products have been recognized as bioactive agents with several properties, including anti-protozoal and anti-inflammatory activities. The present review focuses on the antileishmanial activity of plant-derived natural products that are able to modulate the inflammatory response in vitro and in vivo. The capability of crude extracts and some isolated substances in promoting an anti-inflammatory response during Leishmania infection may be used as part of an effective strategy to fight the disease.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/835910