Long-Term Neurophysiological Outcomes in Patients Undergoing Coronary Artery Bypass Grafting

Introduction: This study aims to evaluate late postoperative neurophysiological outcomes in patients after coronary artery bypass grafting (CABG). Methods: Forty-five male patients with stable coronary artery disease aged 45-69 years underwent extended neuropsychological assessment using the softwar...

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Published in:Revista brasileira de cirurgia cardiovascular 2021-01, Vol.36 (5), p.629-638
Main Authors: Tarasova, Irina V., Trubnikova, Olga A., Syrova, Irina D., Barbarash, Olga L.
Format: Article
Language:English
Subjects:
Alpha Rhythm
CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular disease
Cognitive ability
Cognitive Dysfunction
Coronary Artery Bypass
Coronary vessels
Cysts
Dementia
Electrodes
Electroencephalography
Executive function
Fourier transforms
Heart surgery
Memory
Neurophysiological Tests
Neuropsychology
Original
Patients
Postoperative Cognitive Complications
Postoperative period
Software
SURGERY
Tomography
Ultrasonic imaging
Variables
Variance analysis
Vein & artery diseases
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Summary:Introduction: This study aims to evaluate late postoperative neurophysiological outcomes in patients after coronary artery bypass grafting (CABG). Methods: Forty-five male patients with stable coronary artery disease aged 45-69 years underwent extended neuropsychological assessment using the software Status PF and electroencephalographical examination 3-5 days before CABG and 5-7 years after CABG. Postoperative decline in cognitive functions was determined by a 20% decrease in the cognitive indicator compared to that at baseline on 20% of the tests included in the Status PF battery. Statistical analysis was performed using the software STATISTICA 10.0. Multiple regression was used to identify demographic, clinical, and electroencephalographical variables associated with adverse cognitive outcomes. Results: Cognitive decline was observed in 54% of the patients in the long-term postoperative period. Five to seven years after CABG, all patients have shown an increase in the theta rhythm power compared to the preoperative values, which is most pronounced in the frontal and temporal areas of the right hemisphere (P=0.04), along with a decrease in the alpha rhythm in the posterior areas of the cortex (P=0.005). Multiple regression has reported that the main predictors of cognitive impairment are slower mean alpha frequency, decreased theta-2 rhythm with eyes closed in the right temporal area, and increased theta-2 rhythm with eyes open in the left temporal area (F(5.39)=8.81; P
ISSN:1678-9741
0102-7638
1678-9741
DOI:10.21470/1678-9741-2020-0390