Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study

• Published in: Aging brain 2024-01, Vol.5, p.100105, Article 100105
• Main Authors: Khalilian, Maedeh, Toba, Monica N., Roussel, Martine, Tasseel-Ponche, Sophie, Godefroy, Olivier, Aarabi, Ardalan
• Format: Article
• Language: English
• Subjects: Aging; Brain functional connectivity; Brain structural connectivity; Cognitive science; Neuroscience; Rich-club organization; Structure–function coupling; Vulnerability analysis
• ISSN: 2589-9589; 2589-9589
• DOI: 10.1016/j.nbas.2023.100105

We investigated age-related trends in the topology and hierarchical organization of brain structural and functional networks using diffusion-weighted imaging and resting-state fMRI data from a large cohort of healthy aging adults. At the cross-modal level, we explored age-related patterns in the RC involvement of different functional subsystems using a high-resolution functional parcellation. We further assessed age-related differences in the structure–function coupling as well as the network vulnerability to damage to rich club connectivity. Regardless of age, the structural and functional brain networks exhibited a rich club organization and small-world topology. In older individuals, we observed reduced integration and segregation within the frontal-occipital regions and the cerebellum along the brain's medial axis. Additionally, functional brain networks displayed decreased integration and increased segregation in the prefrontal, centrotemporal, and occipital regions, and the cerebellum. In older subjects, structural networks also exhibited decreased within-network and increased between-network RC connectivity. Furthermore, both within-network and between-network RC connectivity decreased in functional networks with age. An age-related decline in structure–function coupling was observed within sensory-motor, cognitive, and subcortical networks. The structural network exhibited greater vulnerability to damage to RC connectivity within the language-auditory, visual, and subcortical networks. Similarly, for functional networks, increased vulnerability was observed with damage to RC connectivity in the cerebellum, language-auditory, and sensory-motor networks. Overall, the network vulnerability decreased significantly in subjects older than 70 in both networks. Our findings underscore significant age-related differences in both brain functional and structural RC connectivity, with distinct patterns observed across the adult lifespan.