Seroprevalence of adeno-associated virus types 1, 2, 3, 4, 5, 6, 8, and 9 in a Basque cohort of healthy donors

Adeno-associated viruses (AAVs) are promising gene therapy vectors, but challenges arise when treating patients with preexisting neutralizing antibodies. Worldwide seroprevalence studies provide snapshots of existing immunity in diverse populations. Owing to the uniqueness of the Basque socio-geogra...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.15941-8, Article 15941
Main Authors: Navarro-Oliveros, Miguel, Vidaurrazaga, Ander, Soares Guerra, Gabriel, Castellana, Donatello, Embade, Nieves, Millet, Oscar, Marigorta, Urko M., Abrescia, Nicola G. A.
Format: Article
Language:English
Subjects:
631/61/201
631/61/2300/1514
692/308/174
Adeno-associated virus
Adult
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Basque population
Cohort Studies
Dependovirus - genetics
Dependovirus - immunology
Drug development
Expression vectors
Female
Gene therapy
Health care
Humanities and Social Sciences
Humans
Immune system
Male
Middle Aged
multidisciplinary
Parvoviridae Infections - epidemiology
Parvoviridae Infections - immunology
Parvoviridae Infections - virology
Population studies
Public health
Science
Science (multidisciplinary)
Seroepidemiologic Studies
Serogroup
Serology
Seroprevalence
Serotypes
Spain - epidemiology
Vectors (Biology)
Viruses
Young Adult
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Description
Summary:Adeno-associated viruses (AAVs) are promising gene therapy vectors, but challenges arise when treating patients with preexisting neutralizing antibodies. Worldwide seroprevalence studies provide snapshots of existing immunity in diverse populations. Owing to the uniqueness of the Basque socio-geographical landscape, we investigated the seroprevalence of eight AAV serotypes in residents of the Basque Country. We found the highest seroprevalence of AAV3, and the lowest seroprevalence of AAV9. Additionally, less than 50% of the Basque population has neutralizing antibodies against AAV4, AAV6, and AAV9. Our findings provide insight into AAV infections in the Basque region, public health, and the development of AAV-based therapeutics.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-66546-4