Electrospun Membrane Based on Poly(L-co-D,L lactic acid) and Natural Rubber Containing Copaiba Oil Designed as a Dressing with Antimicrobial Properties

Drug delivery systems of natural antimicrobial compounds, such as copaiba oil (CO), have become relevant in the scientific community due to the recent prevalence of the public health complications related to antibiotic resistance. Electrospun devices act as an efficient drug delivery system for thes...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-05, Vol.12 (5), p.898
Main Authors: Pinto, Marcelo Formigoni, Quevedo, Bruna V, Asami, Jessica, Komatsu, Daniel, Hausen, Moema de Alencar, Duek, Eliana Aparecida de Rezende
Format: Article
Language:English
Subjects:
antibacterial
Antibacterial activity
Antibacterial agents
antibacteriostatic
Antibiotic resistance
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
Bacterial infections
Barriers
Bioactive compounds
Biofilms
Complications
Design
Drug delivery
Drug delivery systems
Drug resistance in microorganisms
Drugs
electrospun membrane
Gentian violet
Health aspects
Lactic acid
Medical dressings
Membranes
natural extract
Natural rubber
PLDLA
Polymers
Public health
Rubber
Scanning electron microscopy
Side effects
Skin
Spectrum analysis
Staphylococcus infections
Vehicles
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Summary:Drug delivery systems of natural antimicrobial compounds, such as copaiba oil (CO), have become relevant in the scientific community due to the recent prevalence of the public health complications related to antibiotic resistance. Electrospun devices act as an efficient drug delivery system for these bioactive compounds, reducing systemic side effects and increasing the effectiveness of the treatment. In this way, the present study aimed to evaluate the synergistic and antimicrobial effect of the direct incorporation of different concentrations of CO in a poly(L-co-D,L lactic acid) and natural rubber (NR) electrospun membrane. It was observed that CO showed bacteriostatic and antibacterial effects against in antibiogram assays. The prevention of biofilm formation was confirmed via scanning electron microscopy. The test with crystal violet demonstrated strong bacteria inhibition in membranes with 75% CO. A decrease in hydrophilicity, observed in the swelling test, presented that the addition of CO promotes a safe environment for the recovery of injured tissue while acting as an antimicrobial agent. In this way, the study showed strong bacteriostatic effects of the CO incorporation in combination with electrospun membranes, a suitable feature desired in wound dressings in order to promote a physical barrier with prophylactic antimicrobial properties to avoid infections during tissue healing.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12050898