4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma

This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line D...

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Bibliographic Details
Published in:Brain sciences 2017-11, Vol.7 (11), p.147
Main Authors: Messerli, Shanta M, Hoffman, Mariah M, Gnimpieba, Etienne Z, Kohlhof, Hella, Bhardwaj, Ratan D
Format: Article
Language:English
Subjects:
4SC-202
bioinformatics
Brain cancer
Brain tumors
Cancer
Cerebellum
Communication
Hedgehog protein
Kinases
Medulloblastoma
microarray
Molecular biology
Neural stem cells
pediatric brain tumor
Pediatrics
Protein-tyrosine kinase
Signal transduction
Stem cells
Therapeutic applications
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Summary:This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci7110147