Generation of two iPSC lines, (ICGi015-A and ICGi015-B), by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease

Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were genera...

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Bibliographic Details
Published in:Stem cell research 2019-12, Vol.41, p.101652-101652, Article 101652
Main Authors: Sharipova, D.V., Kovalenko, V.R., Bairamova, E.M., Vartanova, V.A., Grigor'eva, E.V., Vyatkin, Y.V., Khabarova, E.A., Rzaev, D.A., Zakian, S.M., Medvedev, S.P.
Format: Article
Language:English
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Summary:Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were generated from blood mononuclear cells of PD patient, carrying three SNPs, associated with PD development. The obtained iPSC lines express pluripotency markers and demonstrate the ability to in vitro differentiate into the three germ layers. These cell lines may be useful for studying molecular mechanisms of PD and for drug screening.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2019.101652