The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice

The present study was conducted to evaluate the analgesic potential of the new triamilide macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously against acute pain in mice. Acute pain was induced either chemically (using acetic acid-induced writhing and formalin-...

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Bibliographic Details
Published in:Pharmaceutics 2021-08, Vol.13 (8), p.1247
Main Authors: Elbadawy, Mohamed, Abugomaa, Amira, El-Husseiny, Hussein M., Mandour, Ahmed S., Abdel-Daim, Mohamed M., Aboelenin, Salama Mostafa, Soliman, Mohamed Mohamed, El-Mleeh, Amany
Format: Article
Language:English
Subjects:
analgesic
Analgesics
Animals
anti-nociceptive
Antibiotics
Chemicals
Drug dosages
Experiments
macrolides
Nervous system
Pain
Pharmaceuticals
tulathromycin
Veterinary medicine
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Summary:The present study was conducted to evaluate the analgesic potential of the new triamilide macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously against acute pain in mice. Acute pain was induced either chemically (using acetic acid-induced writhing and formalin-induced pain tests) or thermally (using hot-plate, and tail-flick tests). In the acetic acid-induced writhing test, tulathromycin induced a dose-dependent and significant decrease in the number of writhes compared with the control group. In the late phase of the formalin test, a significant decline in hind paw licking time compared with the control group was observed. In the hot-plate and tail-flick tests, tulathromycin caused a dose-dependent and significant prolongation of latency of nociceptive response to heat stimuli, compared with the control group. These findings may indicate that tulathromycin possesses significant peripheral and central analgesic potentials that may be valuable in symptomatic relief of pain, in addition to its well-established antibacterial effect.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13081247