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Growth factors in lung development and disease: friends or foe?

Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in...

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Published in:	Respiratory research 2001-10, Vol.3 (1), p.2-2, Article 2
Main Authors:	Desai, Tushar J, Cardoso, Wellington V
Format:	Article
Language:	English
Subjects:	airway branching Analysis Animals Care and treatment Cell differentiation Diagnosis Growth factors Growth Substances - metabolism Growth Substances - therapeutic use Health aspects Homeopathy Humans Lung - growth & development Lung - metabolism lung development Lung diseases Lung Diseases - drug therapy Lung Diseases - metabolism lung injury-repair Materia medica and therapeutics Risk factors Therapeutics
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description	Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor beta1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.
doi_str_mv	10.1186/rr169
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subjects	airway branching Analysis Animals Care and treatment Cell differentiation Diagnosis Growth factors Growth Substances - metabolism Growth Substances - therapeutic use Health aspects Homeopathy Humans Lung - growth & development Lung - metabolism lung development Lung diseases Lung Diseases - drug therapy Lung Diseases - metabolism lung injury-repair Materia medica and therapeutics Risk factors Therapeutics
title	Growth factors in lung development and disease: friends or foe?
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