Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure

Hematological malignancies, including multiple myeloma, lymphoma, and leukemia, are a heterogeneous group of neoplasms that affect the blood, bone marrow, and lymph nodes. They originate from uncontrolled growth of hematopoietic and lymphoid cells from different stages in their maturation/differenti...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-01, Vol.22 (3), p.1026
Main Authors: Uribe-Herranz, Mireia, Klein-González, Nela, Rodríguez-Lobato, Luis Gerardo, Juan, Manel, de Larrea, Carlos Fernández
Format: Article
Language:English
Subjects:
allogeneic stem cell transplantation
Animals
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
autologous stem cell transplant
bacterial metabolites
chemotherapy
Gastrointestinal Microbiome
Hematologic Neoplasms - immunology
Hematologic Neoplasms - microbiology
Hematologic Neoplasms - therapy
hematological malignancies
Host-Pathogen Interactions - drug effects
Host-Pathogen Interactions - immunology
Humans
Immunotherapy, Adoptive
microbiota
Review
Stem Cell Transplantation
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Summary:Hematological malignancies, including multiple myeloma, lymphoma, and leukemia, are a heterogeneous group of neoplasms that affect the blood, bone marrow, and lymph nodes. They originate from uncontrolled growth of hematopoietic and lymphoid cells from different stages in their maturation/differentiation and account for 6.5% of all cancers around the world. During the last decade, it has been proven that the gut microbiota, more specifically the gastrointestinal commensal bacteria, is implicated in the genesis and progression of many diseases. The immune-modulating effects of the human microbiota extend well beyond the gut, mostly through the small molecules they produce. This review aims to summarize the current knowledge of the role of the microbiota in modulating the immune system, its role in hematological malignancies, and its influence on different therapies for these diseases, including autologous and allogeneic stem cell transplantation, chemotherapy, and chimeric antigen receptor T cells.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22031026