Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study

Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of...

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Bibliographic Details
Published in:Clinical, cosmetic and investigational dermatology cosmetic and investigational dermatology, 2017-01, Vol.10, p.373-384
Main Authors: Augustin, Matthias, Goepel, Lisa, Jacobi, Arnd, Bosse, Bjoern, Mueller, Stefan, Hopp, Michael
Format: Article
Language:English
Subjects:
Acne
acne vulgaris
Antibiotics
atopic dermatitis
Bacteria
Care and treatment
Clinical trials
Dermatitis
Dermatology
Eczema
Family medical history
Health aspects
Hydrogels
impetigo contagiosa
Iodine
liposomal PVP-iodine hydrogel
Liposomes
Original Research
polyvinylpyrrolidone
Pyrroles
Rosacea
Skin
Skin diseases
Thyroid gland
Wound healing
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Summary:Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. In this prospective, single-arm (uncontrolled), open-label Phase II pilot study, patients with acne vulgaris (n=30), atopic dermatitis (n=20), impetigo contagiosa (n=10), and rosacea (n=10) received PVP-iodine (3%) hydrogel for ≤4 weeks. Global Clinical Severity score improved for all dermatoses (range: 0.5 for acne vulgaris [
ISSN:1178-7015
1178-7015
DOI:10.2147/CCID.S141887