Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a key role in PE pathogenesis but its contribution to PE during GDM remains unclear. Herein, we compared placental and maternal bl...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.2312-2312, Article 2312
Main Authors: Nuzzo, Anna Maria, Giuffrida, Domenica, Moretti, Laura, Re, Paola, Grassi, Giorgio, Menato, Guido, Rolfo, Alessandro
Format: Article
Language:English
Subjects:
631/208
631/337
631/443
692/163
692/4017
692/420
692/53
692/699
Adult
Angiogenesis
Biomarkers - metabolism
Blood
Diabetes mellitus
Diabetes, Gestational - metabolism
Female
Gene expression
Gestational diabetes
Humanities and Social Sciences
Humans
Immunoassays
Kinases
Molecular Biology
multidisciplinary
Placenta
Placenta - metabolism
Placenta Growth Factor - genetics
Placenta Growth Factor - metabolism
Pre-eclampsia
Preeclampsia
Pregnancy
Protein-tyrosine kinase
Science
Science (multidisciplinary)
Vascular Endothelial Growth Factor Receptor-1 - genetics
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a key role in PE pathogenesis but its contribution to PE during GDM remains unclear. Herein, we compared placental and maternal blood anti-angiogenic soluble fms-like tyrosine kinase-1 (sFlt1) and pro-angiogenic Placental Growth Factor (PlGF) expressions in GDM and GDM-PE pregnancies compared to controls (CTRL) and PE cases. Electrochemiluminescence immunoassays showed a significantly higher maternal blood sFlt1/PlGF values in GDM-PE relative to CTRL and GDM pregnancies. We reported that placental PlGF gene expression was significantly decreased in GDM, PE and GDM-PE relative to CTRL. However, PlGF protein levels were significantly increased in GDM and GDM-PE relative to CTRL and PE placentae. Finally, sFlt1 gene expression was significantly increased in PE relative to CTRL, GDM and GDM-PE placentae. In contrast, sFlt1 protein expression was significantly decreased in GDM-PE relative to CTRL, GDM and PE placentae. Finally, higher sFlt1/PlGF ratio in GDM-PE maternal blood suggest that sFlt1 overproduction is related to PE onset also in GDM pregnancies even though characterized by a less severe endothelial dysfunction in terms of angiogenic biomarkers.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-81785-5