Immune-related arthritis following pelvic radiation therapy in a patient with lung cancer receiving long-term immune checkpoint blocker treatment: Case report

Radiotherapy can trigger immune-related out-of-field "abscopal" response. We report a patient with advanced NSCLC (non-small cell lung cancer) receiving long-term anti-PD1 (programmed cell death protein 1) who have developed out-of-field immune-related arthritis following pelvic irradiatio...

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Bibliographic Details
Published in:Frontiers in immunology 2022-10, Vol.13, p.920130
Main Authors: Aldea, Mihaela, Belkhir, Rakiba, Colomba, Emeline, Blanchard, Pierre, Danlos, Francois-Xavier, Botticella, Angela, Terlizzi, Mario, Deutsch, Eric, Le Péchoux, Cecile, Planchard, David, Michot, Jean-Marie, Besse, Benjamin, Levy, Antonin
Format: Article
Language:English
Subjects:
adverse (side) effects
anti-PD(L)1
Arthritis
Cancer
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - radiotherapy
Humans
Immune Checkpoint Inhibitors - adverse effects
Immunology
immunoradiotherapy
immunotherapy
Life Sciences
Lung Neoplasms
radiation therapy
toxicity
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Summary:Radiotherapy can trigger immune-related out-of-field "abscopal" response. We report a patient with advanced NSCLC (non-small cell lung cancer) receiving long-term anti-PD1 (programmed cell death protein 1) who have developed out-of-field immune-related arthritis following pelvic irradiation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.920130