Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer

Background. The interventions for hemorrhoid increase access to rectal cancer screening and thus might reduce cancer death. We aimed to examine the impact of hemorrhoid on survival outcomes in rectal cancer. Methods. We identified 510 patients with stage I to III rectal cancer from a prospectively c...

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Bibliographic Details
Published in:Gastroenterology research and practice 2020, Vol.2020 (2020), p.1-10
Main Authors: Yu, Huichuan, Huang, Meijin, Tang, Guannan, Bai, Liangliang, Wang, Xiaolin, Ren, Donglin, Zou, Qi, Luo, Yanxin
Format: Article
Language:English
Subjects:
Abdomen
Age
Ambulatory care
Body mass index
Cancer
Cancer patients
Colonoscopy
Colorectal cancer
Diagnosis
Disease
Endoscopy
Hemorrhoids
Inflammatory bowel disease
Lymphocytes
Medical prognosis
Medical records
Medical screening
Metastasis
Neutrophils
Patient outcomes
Patients
Surgeons
Surgery
Variables
Varicose veins
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Summary:Background. The interventions for hemorrhoid increase access to rectal cancer screening and thus might reduce cancer death. We aimed to examine the impact of hemorrhoid on survival outcomes in rectal cancer. Methods. We identified 510 patients with stage I to III rectal cancer from a prospectively collected database. Patients were divided into hemorrhoid and non-hemorrhoid group. The primary endpoints were disease-free survival (DFS) and overall survival (OS). Results. Hemorrhoid group had significantly more stage I-II diseases in comparison to nonhemorrhoid group (71.1% vs. 55.9%, P=0.049). The hemorrhoid group had significantly better DFS and OS compared to nonhemorrhoid group, the hazard ratios (HRs) of which were 0.39 (95% CI 0.17-0.88, P=0.018) and 0.33 (95% CI 0.12-0.92, P=0.034), respectively. Multivariate analysis revealed that hemorrhoid was independently associated with DFS [adjusted HR 0.43 (95% CI 0.17-0.95, P=0.045)]. A nomogram for predicting DFS outcome was generated based on hemorrhoid history, with a concordance index of 0.71 (95% CI 0.66-0.75, P
ISSN:1687-6121
1687-630X
DOI:10.1155/2020/5045142