Comparative Immune Response in Children and Adults with H. pylori Infection

Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including...

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Bibliographic Details
Published in:Journal of immunology research 2015-01, Vol.2015 (2015), p.1-6
Main Authors: Shirzad, Hedaytollah, Rahimian, Ghorbanali, Shirzad, Mahsa, Azadegan-Dehkordi, Fatemeh, Bagheri, Nader, Razavi, Alireza, Rafieian-Kopaei, Mahmoud
Format: Article
Language:English
Subjects:
Adult
Age Factors
Antigens
Child
Child, Preschool
Colleges & universities
Cytokines
Dendritic cells
Families & family life
Helicobacter Infections - immunology
Helicobacter Infections - metabolism
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - immunology
Helicobacter pylori - pathogenicity
Host-Pathogen Interactions - immunology
Humans
Immune system
Immunity
Immunology
Infections
Inflammation
Inflammatory bowel disease
Review
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Ulcers
Virulence Factors - genetics
Virulence Factors - immunology
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Summary:Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including IL-6, IL-10, and TGF-β1 as well as Foxp3+ cell numbers have been shown to be higher; however, some other cytokines consisting of IL-1β, IL-17A, and IL-23 are lower in infected children than in infected adults. Immune response to H. pylori infection in children is predominant Treg instead of Th17 cell response. These results indicate that immune system responses probably play a role in persistent H. pylori infection. Childhood H. pylori infection is also associated with significantly lower levels of inflammation and ulceration compared with adults. This review, therefore, aimed to provide critical findings of the available literature about comparative immune system in children and adults with H. pylori infection.
ISSN:2314-8861
2314-7156
DOI:10.1155/2015/315957