Nanotechnology-Employed Bacteria-Based Delivery Strategy for Enhanced Anticancer Therapy

Bacteria and their derivatives (membrane vesicles, MVs) exhibit great advantages for targeting hypoxic tumor cores, strong penetration ability and activating immune responses, holding great potential as auspicious candidates for therapeutic and drug-delivery applications. However, the safety issues...

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Bibliographic Details
Published in:International journal of nanomedicine 2021-01, Vol.16, p.8069-8086
Main Authors: Ye, Zixuan, Liang, Lizhen, Lu, Huazhen, Shen, Yan, Zhou, Wenwu, Li, Yanan
Format: Article
Language:English
Subjects:
Antigens
Antineoplastic Agents - therapeutic use
Bacteria
BCG
BCG vaccines
Bladder cancer
Cancer
Cancer therapies
Care and treatment
Cytokines
Drug Delivery Systems
Drugs
E coli
Efficiency
Genetic engineering
Genetically modified organisms
Health aspects
Humans
Immune response
Listeria
membrane vesicles
nanomaterial
Nanomaterials
Nanoparticles
Nanotechnology
Neoplasms - drug therapy
Review
Salmonella
targeted delivery
Technology application
Tetracycline
Tetracyclines
Tumors
Vaccines
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Summary:Bacteria and their derivatives (membrane vesicles, MVs) exhibit great advantages for targeting hypoxic tumor cores, strong penetration ability and activating immune responses, holding great potential as auspicious candidates for therapeutic and drug-delivery applications. However, the safety issues and low therapeutic efficiency by single administration still need to be solved. To further optimize their performance and to utilize their natural abilities, scientists have strived to modify bacteria with new moieties on their surface while preserving their advantages. The aim of this review is to give a comprehensive overview of a non-genetic engineering modification strategy that can be used to optimize the bacteria with nanomaterials and the design strategy that can be used to optimize MVs for better targeted therapy. Here, the advantages and disadvantages of these processes and their applicability for the development of bacteria-related delivery system as antitumor therapeutic agents are discussed. The prospect and the challenges of the above targeted delivery system are also proposed.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S329855