ApoA-I Mimetic Peptide Reduces Vascular and White Matter Damage After Stroke in Type-2 Diabetic Mice

Diabetes leads to an elevated risk of stroke and worse functional outcome compared to the general population. We investigate whether L-4F, an economical ApoA-I mimetic peptide, reduces neurovascular and white-matter damage in db/db type-2 diabetic (T2DM) stroke mice. L-4F (16mg/kg, subcutaneously ad...

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Bibliographic Details
Published in:Frontiers in neuroscience 2019-10, Vol.13, p.1127-1127
Main Authors: Wang, Xiaohui, Li, Rongwen, Zacharek, Alex, Landschoot-Ward, Julie, Chopp, Michael, Chen, Jieli, Cui, Xu
Format: Article
Language:English
Subjects:
Animals
Aorta
Apolipoproteins
Atherosclerosis
Blood-brain barrier
blood–brain barrier (BBB)
Brain injury
Cell number
Cerebral blood flow
Diabetes
Diabetes mellitus
Embryos
Endothelial cells
Glucose
Glycosylation
Hemorrhage
Inflammation
Ischemia
Laboratories
Leukocyte migration
Lipids
Lipoproteins
Macrophages
Medical prognosis
Metastases
Nervous system
Neuroscience
Neurosciences
Oxygen
Peptides
Plasminogen activator inhibitors
Smooth muscle
Stroke
Substantia alba
Tumor necrosis factor-α
white matter (WM)
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Summary:Diabetes leads to an elevated risk of stroke and worse functional outcome compared to the general population. We investigate whether L-4F, an economical ApoA-I mimetic peptide, reduces neurovascular and white-matter damage in db/db type-2 diabetic (T2DM) stroke mice. L-4F (16mg/kg, subcutaneously administered initially 2h after stroke and subsequently daily for 4 days) reduced hemorrhagic transformation, decreased infarct-volume and mortality, and treated mice exhibited increased cerebral arteriole diameter and smooth muscle cell number, decreased blood-brain barrier leakage and white-matter damage in the ischemic brain as well as improved neurological functional outcome after stroke compared with vehicle-control T2DM mice (p
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2019.01127