Post-Pemphigus Acanthomata Presenting as an Isolated, Hyperkeratotic Plaque

Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally, a case report by Ohashi et al. reported simi...

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Bibliographic Details
Published in:Dermatopathology (Basel, Switzerland) Switzerland), 2023-03, Vol.10 (1), p.86-90
Main Authors: Pandya, Rachita, Zhou, Yanjia, Desai, Mansee, Anderson, Nancy, Elsensohn, Ashley
Format: Article
Language:English
Subjects:
acantholysis
acanthosis
Biopsy
Case Report
Conflicts of interest
Disease
Erythema
Hair
Histology
Histopathology
hyperkeratosis
Patients
pemphigus vulgaris
Remission (Medicine)
Skin cancer
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Summary:Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally, a case report by Ohashi et al. reported similar recalcitrant lesions on the trunk of a patient with pemphigus foliaceus being treated with prednisolone, IVIG, plasma exchange, and cyclosporine. Some view post-pemphigus acanthomas as variants of hypertrophic pemphigus vulgaris, being difficult to diagnose when they present as only single lesions, with a clinical differential of an inflamed seborrheic keratosis or squamous cell carcinoma. Here, we present a case of a 52-year-old female with a history of pemphigus vulgaris and four months of only topical therapy (fluocinonide 0.05%) who presented with a painful, hyperkeratotic plaque on the right mid-back that was found to be a post-pemphigus acanthoma.
ISSN:2296-3529
2296-3529
DOI:10.3390/dermatopathology10010012