Nervous System of Periplaneta americana Cockroach as a Model in Toxinological Studies: A Short Historical and Actual View

Nervous system of Periplaneta americana cockroach is used in a wide range of pharmacological studies, including electrophysiological techniques. This paper presents its role as a preparation in the development of toxinological studies in the following electrophysiological methods: double-oil-gap tec...

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Bibliographic Details
Published in:Journal of Toxicology 2012-01, Vol.2012 (2012), p.70-80
Main Authors: Stankiewicz, Maria, De Lima, Maria Elena, Dąbrowski, Marcin
Format: Article
Language:English
Subjects:
Abdomen
Experiments
Molecular weight
Nervous system
Periplaneta americana
Review
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Summary:Nervous system of Periplaneta americana cockroach is used in a wide range of pharmacological studies, including electrophysiological techniques. This paper presents its role as a preparation in the development of toxinological studies in the following electrophysiological methods: double-oil-gap technique on isolated giant axon, patch-clamp on DUM (dorsal unpaired median) neurons, microelectrode technique in situ conditions on axon in connective and DUM neurons in ganglion, and single-fiber oil-gap technique on last abdominal ganglion synapse. At the end the application of cockroach synaptosomal preparation is mentioned.
ISSN:1687-8191
1687-8205
DOI:10.1155/2012/143740