Microneedle patch as a new platform to effectively deliver inactivated polio vaccine and inactivated rotavirus vaccine

We recently reported a lack of interference between inactivated rotavirus vaccine (IRV) and inactivated poliovirus vaccine (IPV) and their potential dose sparing when the two vaccines were administered intramuscularly either in combination or standalone in rats and guinea pigs. In the present study,...

Full description

Saved in:
Bibliographic Details
Published in:npj vaccines 2022-02, Vol.7 (1), p.26-26, Article 26
Main Authors: Moon, Sung-Sil, Richter-Roche, Marly, Resch, Theresa K., Wang, Yuhuan, Foytich, Kimberly R., Wang, Houping, Mainou, Bernardo A., Pewin, Winston, Lee, Jeongwoo, Henry, Sebastien, McAllister, Devin V., Jiang, Baoming
Format: Article
Language:English
Subjects:
631/61/24/590
692/699/255/2514
Biomedical and Life Sciences
Biomedicine
Drug delivery systems
Immunogenicity
Infectious Diseases
Medical Microbiology
Public Health
Rodents
Rotavirus
Vaccine
Vaccines
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We recently reported a lack of interference between inactivated rotavirus vaccine (IRV) and inactivated poliovirus vaccine (IPV) and their potential dose sparing when the two vaccines were administered intramuscularly either in combination or standalone in rats and guinea pigs. In the present study, we optimized the formulations of both vaccines and investigated the feasibility of manufacturing a combined IRV-IPV dissolving microneedle patch (dMNP), assessing its compatibility and immunogenicity in rats. Our results showed that IRV delivered by dMNP alone or in combination with IPV induced similar levels of RV-specific IgG and neutralizing antibody. Likewise, IPV delivered by dMNP alone or in combination with IRV induced comparable levels of neutralizing antibody of poliovirus types 1, 2, and 3. We further demonstrated high stability of IRV-dMNP at 5, 25, and 40 °C and IPV-dMNP at 5 and 25 °C, and found that three doses of IRV or IPV when co-administered at a quarter dose was as potent as a full target dose in inducing neutralizing antibodies against corresponding rotavirus or poliovirus. We conclude that IRV-IPV dMNP did not interfere with each other in triggering an immunologic response and were highly immunogenic in rats. Our findings support the further development of this innovative approach to deliver a novel combination vaccine against rotavirus and poliovirus in children throughout the world.
ISSN:2059-0105
2059-0105
DOI:10.1038/s41541-022-00443-7