AQP4, Astrogenesis, and Hydrocephalus: A New Neurological Perspective

Aquaporin 4 (AQP4) is a cerebral glial marker that labels ependymal cells and astrocytes' endfeet and is the main water channel responsible for the parenchymal fluid balance. However, in brain development, AQP4 is a marker of glial stem cells and plays a crucial role in the pathophysiology of p...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (18), p.10438
Main Authors: Castañeyra-Ruiz, Leandro, González-Marrero, Ibrahim, Hernández-Abad, Luis G, Lee, Seunghyun, Castañeyra-Perdomo, Agustín, Muhonen, Michael
Format: Article
Language:English
Subjects:
Adults
AQP4
Aquaporin 4
Astrocytes
Astrocytes - metabolism
astrogenesis
Biomarkers
Brain
Child
Ependymal cells
Etiology
Glial stem cells
Gliogenesis
Gliosis
Homeostasis
Humans
Hydrocephalus
Medical prognosis
Neurogenesis
Neuroglia - metabolism
Neuronal-glial interactions
pediatric hydrocephalus
Pediatrics
Physiology
premature gliogenesis
reactive astrogliosis
Review
Stem cells
Water - metabolism
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Summary:Aquaporin 4 (AQP4) is a cerebral glial marker that labels ependymal cells and astrocytes' endfeet and is the main water channel responsible for the parenchymal fluid balance. However, in brain development, AQP4 is a marker of glial stem cells and plays a crucial role in the pathophysiology of pediatric hydrocephalus. Gliogenesis characterization has been hampered by a lack of biomarkers for precursor and intermediate stages and a deeper understanding of hydrocephalus etiology is needed. This manuscript is a focused review of the current research landscape on AQP4 as a possible biomarker for gliogenesis and its influence in pediatric hydrocephalus, emphasizing reactive astrogliosis. The goal is to understand brain development under hydrocephalic and normal physiologic conditions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810438