Assessment of aortic and peripheral arterial stiffness in patients with knee osteoarthritis by ultrasound Doppler derived pulse wave velocity

• Published in: Scientific reports 2024-01, Vol.14 (1), p.1346-1346, Article 1346
• Main Authors: Yang, Yong, Liang, Xiao, Luo, Hu, Cheng, Yu-xin, Guo, Yan, Wu, Peng, Huang, Yan-li, Zhang, Jin-peng, Wang, Zhen
• Format: Article
• Language: English
• Subjects: 692/53; 692/699/1670; 692/699/75; Ankle; Aorta; Aorta - diagnostic imaging; Arteries; Arthritis; Blood pressure; Blood Pressure - physiology; Body mass index; C-reactive protein; Cardiovascular diseases; Confounding (Statistics); Correlation analysis; Doppler effect; Femur; Health risks; Heart rate; Humanities and Social Sciences; Humans; Knee; Lipids; multidisciplinary; Multiple regression analysis; Osteoarthritis; Osteoarthritis, Knee - diagnostic imaging; Pulse Wave Analysis - methods; Risk Factors; Science; Science (multidisciplinary); Ultrasonic imaging; Ultrasound; Vascular Stiffness - physiology; Velocity; Wave velocity
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-52097-1

Information regarding regional arterial stiffness assessment in osteoarthritis (OA) was scarce and sometimes contradictory. We aimed to investigate the aortic, lower limb peripheral arterial stiffness and their associations with knee OA. Patients with primary knee OA and matched non-OA controls were prospectively enrolled from two medical centers in China. The carotid-femoral pulse wave velocity (cfPWV) and femoral-ankle pulse wave velocity (faPWV) were measured using a novel ultrasound technique. A total of 238 participants (including 128 patients with knee OA and 110 controls) were included. In OA patients, cfPWV was significantly higher than that of non-OA controls (9.40 ± 1.92 vs 8.25 ± 1.26 m/s, P