Autoimmune thyroid disease and ovarian hypofunction: a review of literature

Thyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction. Autoimmune thyroid disease (AITD), one of the most common organ spe...

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Bibliographic Details
Published in:Journal of ovarian research 2024-06, Vol.17 (1), p.125-8
Main Authors: Wang, Ru, Lv, Youyuan, Dou, Tao, Yang, Qian, Yu, Chunxiao, Guan, Qingbo
Format: Article
Language:English
Subjects:
Animals
Antibodies
Autoimmune Diseases - immunology
Autoimmune thyroid disease
B cells
Cytokines
Development and progression
Diseases
Female
Humans
Hyperthyroidism
Hypothyroidism
Ovarian
Ovarian Diseases - immunology
Ovary - immunology
Ovary - physiopathology
Premature ovarian failure
Review
Steroid hormones
Thyroid Diseases - complications
Thyroid Diseases - immunology
Thyroid Diseases - physiopathology
Thyroid hormones
Viral antibodies
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Summary:Thyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction. Autoimmune thyroid disease (AITD), one of the most common organ specific autoimmune diseases, is mainly mediated by cellular autoimmune reactions, and has strong inflammatory infiltration and immune active cells, including chemokines and cytokines, which are important components of ovarian aging. This suggests that autoimmune and inflammatory molecular processes may play a role in the emergence of ovarian dysfunction. The purpose of this review is to summarize recent in vivo and in vitro evidence of a complex relationship between AITD and ovarian dysfunction. AITD is closely related to the decline of ovarian function from the perspective of antibody, cytokine, oxidative stress, and genetic factors. Finally, some of the currently known treatments for AITD and hypo ovarian disease are summarized.
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-024-01451-y