Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer

Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as a study object by circRNA sequenci...

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Published in:Frontiers in cell and developmental biology 2021-09, Vol.9, p.704683-704683
Main Authors: Wang, Feifan, Zhang, Yan, Zhou, Xuejian, Chen, Xianwu, Xiang, Jiayong, Fan, Mengjing, Yu, Yanlan, Cai, Yueshu, Wu, Hongshen, Huang, Shihan, He, Ning, Hu, Zhenghui, Ding, Guoqing, Jin, Xiaodong
Format: Article
Language:English
Subjects:
bladder cancer
Cell and Developmental Biology
circPPP1CB
miR-1307-3p
SMG1
tumorigenesis
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Summary:Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as a study object by circRNA sequencing and quantitative real-time PCR (qRT-PCR) validation in human bladder cancer (BC). CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. Functionally, circPPP1CB modulated cell growth, metastasis, and epithelial-to-mesenchymal transition (EMT) process in vitro and in vivo . Mechanically, we performed various experiments to verify the circPPP1CB/miR-1307-3p/SMG1 regulatory axis. Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR-1307-3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.704683