Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma

Asthma represents a public health problem and traditionally is classified as an atopic disease, where the allergen can induce clinical airway inflammation, bronchial hyperresponsiveness, and reversible obstruction of airways. Studies have demonstrated the presence of T-helper 2 lymphocytes in the lu...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.821-825-273
Main Authors: Vuolo, Francieli, Petronilho, Fabricia, Sonai, Beatriz, Ritter, Cristiane, Hallak, Jaime E. C., Zuardi, Antonio Waldo, Crippa, José A., Dal-Pizzol, Felipe
Format: Article
Language:English
Subjects:
Animals
Asthma
Asthma - drug therapy
Asthma - immunology
Cannabidiol - therapeutic use
Cannabinoids
Care and treatment
Cell growth
Cytokines
Cytokines - blood
Disease Models, Animal
Health aspects
Immunoglobulins
Inflammation
Laboratory animals
Lymphocytes
Male
Ovalbumin - immunology
Rats
Rats, Wistar
Rodents
Studies
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Summary:Asthma represents a public health problem and traditionally is classified as an atopic disease, where the allergen can induce clinical airway inflammation, bronchial hyperresponsiveness, and reversible obstruction of airways. Studies have demonstrated the presence of T-helper 2 lymphocytes in the lung of patients with asthma. These cells are involved in cytokine production that regulates immunoglobulin synthesis. Recognizing that T cell interaction with antigens/allergens is key to the development of inflammatory diseases, the aim of this study is to evaluate the anti-inflammatory potential of cannabidiol (CBD) in this setting. Asthma was induced in 8-week-old Wistar rats by ovalbumin (OVA). In the last 2 days of OVA challenge animals received CBD (5 mg/kg, i.p.) and were killed 24 hours after. The levels of IL-4, IL-5, IL-13, IL-6, IL-10, and TNF-α were determinate in the serum. CBD treatment was able to decrease the serum levels of all analyzed cytokines except for IL-10 levels. CBD seems to be a potential new drug to modulate inflammatory response in asthma.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/538670