RNA-binding proteins in bone pathophysiology

Bone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During this process, intricate communication among all bone cells is required. Indeed, adapt to changing functional situations in the bone, the resorption activity of osteoclasts is tightl...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2024-06, Vol.12, p.1412268
Main Authors: Maroni, Paola, Pesce, Noemi Anna, Lombardi, Giovanni
Format: Article
Language:English
Subjects:
bone aging
bone pathophysiology
Cell and Developmental Biology
modulation of mRNAs
osteoporosis
post-transcriptional regulatory mechanisms
RNA binding proteins (RBPs)
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Summary:Bone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During this process, intricate communication among all bone cells is required. Indeed, adapt to changing functional situations in the bone, the resorption activity of osteoclasts is tightly balanced with the bone formation activity of osteoblasts. Recent studies have reported that RNA Binding Proteins (RBPs) are involved in bone cell activity regulation. RBPs are critical effectors of gene expression and essential regulators of cell fate decision, due to their ability to bind and regulate the activity of cellular RNAs. Thus, a better understanding of these regulation mechanisms at molecular and cellular levels could generate new knowledge on the pathophysiologic conditions of bone. In this Review, we provide an overview of the basic properties and functions of selected RBPs, focusing on their physiological and pathological roles in the bone.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2024.1412268