Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis

Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreati...

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Bibliographic Details
Published in:World journal of surgical oncology 2024-01, Vol.22 (1), p.38-12, Article 38
Main Authors: Liu, Chenming, An, Liang, Zhang, Siyuan, Deng, Shiqing, Wang, Neng, Tang, Haijun
Format: Article
Language:English
Subjects:
Body composition
Cancer
Cancer therapies
Care and treatment
Confidence intervals
Demographic aspects
Health aspects
Humans
Malignancy
Medical prognosis
Meta-analysis
Mortality
Musculoskeletal system
Pancreatic cancer
Pancreatic neoplasm
Pancreatic Neoplasms - complications
Pancreatic Neoplasms - surgery
Prevention
Prognosis
Prospective Studies
Retrospective Studies
Review
Risk factors
Sarcopenia
Sarcopenia - complications
Sarcopenia - diagnosis
Software
Statistical analysis
Surgery
Survival
Systematic review
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Summary:Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreatic cancer after curative-intent surgery. Database from PubMed, Embase, and Web of Science were searched from its inception to July 2023. The primary outcomes were overall survival (OS), progression-free survival (PFS), and the incidence of major complications. The hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CIs) were used to assess the relationship between preoperative sarcopenia and the prognosis of patients with pancreatic cancer. All statistical analyses were conducted by Review Manager 5.3 and STATA 17.0 software. A total of 23 retrospective studies involving 5888 patients were included in this meta-analysis. The pooled results demonstrated that sarcopenia was significantly associated with worse OS (HR = 1.53, P 
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-024-03310-y