Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours

Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of benign serous ovarian tumours are likely primary fibrom...

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Bibliographic Details
Published in:BMC research notes 2020-07, Vol.13 (1), p.349-349, Article 349
Main Authors: Hunter, Sally M, Dall, Genevieve V, Doyle, Maria A, Lupat, Richard, Li, Jason, Allan, Prue, Rowley, Simone M, Bowtell, David, Campbell, Ian G, Gorringe, Kylie L
Format: Article
Language:English
Subjects:
Adenofibroma
Benign
Chromosome 12
Chromosomes
Comparative analysis
Copy number
Copy number aberrations
Copy number variations
Cystadenofibroma
Cystadenomas
Deoxyribonucleic acid
DNA
DNA Copy Number Variations
Exome
Female
Fibroblasts
Fibroma
Fibroma - genetics
Gene expression
Genetic aspects
Genomes
Genomics
Humans
Mutation
Ovarian cancer
Ovarian fibroma
Ovarian Neoplasms - genetics
Ovarian tumors
Research Note
Stromal cells
Trisomy
Tumors
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Summary:Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of benign serous ovarian tumours are likely primary fibromas due to the neoplastic alterations being restricted to the stromal compartment of these tumours. We further explore this finding by comparing benign serous tumours to pure fibromas. Performing copy number aberration (CNA) analysis on the stromal component of 45 benign serous tumours and 8 pure fibromas, we have again shown that trisomy of chromosome 12 is the most common aberration in ovarian fibromas. CNAs were more frequent in the pure fibromas than the benign serous tumours (88% vs 33%), however pure fibromas more frequently harboured more than one CNA event compared with benign serous tumours. As these extra CNA events observed in the pure fibromas were unique to this subset our data indicates a unique tumour evolution. Gene expression analysis on the two cohorts was unable to show gene expression changes that differed based on tumour subtype. Exome analysis did not reveal any recurrently mutated genes.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-020-05194-z