5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice

Oxaliplatin causes peripheral neuropathy as a major dose-limiting side effect, and the control of this neuropathy is difficult. This study was designed to investigate whether prophylactic repetitive administration of 5-HT1A receptor agonists inhibits oxaliplatin-induced mechanical allodynia in mice....

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Bibliographic Details
Published in:Journal of pharmacological sciences 2016-08, Vol.131 (4), p.284-287
Main Authors: Andoh, Tsugunobu, Sakamoto, Ayumi, Kuraishi, Yasushi
Format: Article
Language:English
Subjects:
Animals
Cell Movement - drug effects
Hyperalgesia - chemically induced
Hyperalgesia - immunology
Hyperalgesia - prevention & control
Isoindoles - pharmacology
Male
Mast cells
Mast Cells - cytology
Mast Cells - drug effects
Mice
Naphthalenes - pharmacology
Organoplatinum Compounds
Piperazines - pharmacology
Pyridines - pharmacology
Pyrimidines - pharmacology
Serotonin 5-HT1 Receptor Agonists - pharmacology
Skin - immunology
Tandospirone
Xaliproden
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Summary:Oxaliplatin causes peripheral neuropathy as a major dose-limiting side effect, and the control of this neuropathy is difficult. This study was designed to investigate whether prophylactic repetitive administration of 5-HT1A receptor agonists inhibits oxaliplatin-induced mechanical allodynia in mice. Repetitive administration of 5-HT1A receptor agonists (xaliproden and tandospirone) inhibited mechanical allodynia induced by a single intraperitoneal injection of oxaliplatin. These agonists also inhibited oxaliplatin-induced mast cell migration, which is involved in the induction of mechanical allodynia. These results suggest that the prophylactic repetitive administration of 5-HT1A receptor agonists attenuates oxaliplatin-induced mechanical allodynia by inhibiting the cutaneous mast cell migration.
ISSN:1347-8613
1347-8648
DOI:10.1016/j.jphs.2016.07.008