Role of the DNA Damage Response in Human Papillomavirus RNA Splicing and Polyadenylation

Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-06, Vol.19 (6), p.1735
Main Authors: Nilsson, Kersti, Wu, Chengjun, Schwartz, Stefan
Format: Article
Language:English
Subjects:
Alternative splicing
Basic Medicine
BCLAF1
Binding
Biological evolution
BRCA1
Cell and Molecular Biology
Cell- och molekylärbiologi
DDR
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA damage
DNA Damage - genetics
DNA polymerase
DNA repair
DNA-directed DNA polymerase
Gene expression
Gene Expression Regulation, Viral - genetics
Genomes
HnRNP C
Human behavior
Human papillomavirus
Humans
Machinery and equipment
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Papillomaviridae
Papillomaviridae - genetics
Papillomavirus
Polyadenylation
Polyadenylation - genetics
Polyadenylation - physiology
Progeny
Proteins
Review
RNA processing
RNA Splicing - genetics
RNA-binding protein
Splicing
Splicing factors
SR proteins
TRAP150
U2AF65
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Summary:Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated. Recent research has shown that the DDR factors also interact with RNA binding proteins and affects RNA processing. DDR factors activated by DNA damage and that associate with HPV DNA can recruit splicing factors and RNA binding proteins to the HPV DNA and induce HPV late gene expression. This induction is the result of altered alternative polyadenylation and splicing of HPV messenger RNA (mRNA). HPV uses the DDR machinery to replicate its DNA genome and to activate HPV late gene expression at the level of RNA processing.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19061735