Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance

Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (AR Af ) other than the TR-mutants is a problem in Japan. Additionally, the genetic diversity of A. fumigatus strains in Japan remains relatively unknown. Here we show the diversity...

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Bibliographic Details
Published in:Communications biology 2024-03, Vol.7 (1), p.274-10, Article 274
Main Authors: He, Xiaohui, Kusuya, Yoko, Hagiwara, Daisuke, Toyotome, Takahito, Arai, Teppei, Bian, Cai, Nagayama, Masaki, Shibata, Saho, Watanabe, Akira, Takahashi, Hiroki
Format: Article
Language:English
Subjects:
45/23
45/43
45/77
631/326/193/2484
631/326/193/2539
631/326/193/2541
631/326/325/2484
692/699/255/1672
Aspergillus fumigatus
Aspergillus fumigatus - genetics
Azoles - pharmacology
Biomedical and Life Sciences
Drug Resistance, Fungal - genetics
Genetic diversity
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Japan
Life Sciences
Mutants
Population studies
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Summary:Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (AR Af ) other than the TR-mutants is a problem in Japan. Additionally, the genetic diversity of A. fumigatus strains in Japan remains relatively unknown. Here we show the diversity in the A. fumigatus strains isolated in Japan as well as the complexity in the global distribution of the pathogenic strains. First, we analyzed the genome sequences of 171 strains from Japan as well as the antifungal susceptibility of these strains. Next, we conducted a population analysis of 876 strains by combining the available genomic data for strains isolated worldwide, which were grouped in six clusters. Finally, a genome-wide association study identified the genomic loci associated with AR Af strains, but not the TR-mutants. These results highlight the complexity of the genomic mechanism underlying the emergence of AR Af strains other than the TR-mutants. Whole-genome analysis of 876 Aspergillus fumigatus strains including 171 strains from Japan highlights the diversity in the A. fumigatus strains isolated in Japan as well as the complexity in the global distribution of the pathogenic strains.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-024-05902-6