The frequency gradient of human resting-state brain oscillations follows cortical hierarchies

The human cortex is characterized by local morphological features such as cortical thickness, myelin content, and gene expression that change along the posterior-anterior axis. We investigated if some of these structural gradients are associated with a similar gradient in a prominent feature of brai...

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Bibliographic Details
Published in:eLife 2020-08, Vol.9
Main Authors: Mahjoory, Keyvan, Schoffelen, Jan-Mathijs, Keitel, Anne, Gross, Joachim
Format: Article
Language:English
Subjects:
Adult
Analysis
brain oscillations
Brain Waves - physiology
Cerebral Cortex - physiology
cortical hierarchy
cortical thickness
Female
Gene expression
Humans
Male
MEG
Neuroscience
peak frequency
structure-function relationship in brain
Young Adult
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Summary:The human cortex is characterized by local morphological features such as cortical thickness, myelin content, and gene expression that change along the posterior-anterior axis. We investigated if some of these structural gradients are associated with a similar gradient in a prominent feature of brain activity - namely the frequency of oscillations. In resting-state MEG recordings from healthy participants (N = 187) using mixed effect models, we found that the dominant peak frequency in a brain area decreases significantly along the posterior-anterior axis following the global hierarchy from early sensory to higher order areas. This spatial gradient of peak frequency was significantly anticorrelated with that of cortical thickness, representing a proxy of the cortical hierarchical level. This result indicates that the dominant frequency changes systematically and globally along the spatial and hierarchical gradients and establishes a new structure-function relationship pertaining to brain oscillations as a core organization that may underlie hierarchical specialization in the brain.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.53715