Enhanced sensitive love wave surface acoustic wave sensor designed for immunoassay formats

We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to other surface plasmon re...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2015-05, Vol.15 (5), p.10511-10525
Main Authors: Puiu, Mihaela, Gurban, Ana-Maria, Rotariu, Lucian, Brajnicov, Simona, Viespe, Cristian, Bala, Camelia
Format: Article
Language:English
Subjects:
aflatoxin B1
Antibodies
Antigens
Biomarkers
Immunoassay
Immunoassay - methods
Immunosensors
Liquids
Love waves
Molecular weight
Plasmons
Point of care testing
Sensors
Sound
surface acoustic wave
Surface acoustic waves
surface plasmon resonance
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Summary:We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis. The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable devices, suitable for point-of-care testing (POCT) applications.
ISSN:1424-8220
1424-8220
DOI:10.3390/s150510511