Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variat...

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Bibliographic Details
Published in:Acta veterinaria scandinavica 2017-07, Vol.59 (1), p.51-51, Article 51
Main Authors: Kim, Suhee, Yu, Do-Hyeon, Chae, Jeong-Byoung, Choi, Kyoung-Seong, Kim, Hyeon-Cheol, Park, Bae-Keun, Chae, Joon-Seok, Park, Jinho
Format: Article
Language:English
Subjects:
Anemia
Anemia - complications
Anemia - parasitology
Anemia - veterinary
Animals
Antigens, Protozoan - genetics
Beef cattle
Blood
Brief Communication
Cattle
Cattle Diseases - epidemiology
Cattle Diseases - parasitology
Disease
Diseases and pests
Epidemics
Erythrocytes
Female
Gene expression
Genetic aspects
Genetic diversity
Genotype
Hematology
Infections
Major piroplasm surface protein
Male
MPSP type 1
Outbreaks
Parasites
Pathogenicity
Pathogens
Physiological aspects
Polymerase Chain Reaction - veterinary
Proteins
Protozoan Proteins - genetics
Republic of Korea - epidemiology
Theileria
Theileria - genetics
Theileria orientalis
Theileriasis - complications
Theileriasis - epidemiology
Theileriasis - parasitology
Theileriosis
Variance analysis
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Summary:Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.
ISSN:1751-0147
0044-605X
1751-0147
DOI:10.1186/s13028-017-0318-8