The roles of adenosine signaling in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multiple etiological factors. Immune disorder contributes to SLE development and is an important clinical manifestation of SLE patients. Immune dysfunction is characterized by abnormal of B cells, T cells, monocyte-macrophages a...

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Bibliographic Details
Published in:Heliyon 2024-05, Vol.10 (9), p.e29848-e29848, Article e29848
Main Authors: Dong, Ke, Wu, Xia-nan, Liu, Ying-qi, Yang, Lan, Liu, Chong, Wang, Hui-ping, Gao, Zhao-wei
Format: Article
Language:English
Subjects:
Adenosine
Adenosine deaminase
CD39
CD73
Review
Systemic lupus erythematosus
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Summary:Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multiple etiological factors. Immune disorder contributes to SLE development and is an important clinical manifestation of SLE patients. Immune dysfunction is characterized by abnormal of B cells, T cells, monocyte-macrophages and dendritic cells (DCs), in both quantity and quality. Adenosine is a critical factor for human immune homeostasis, which acts as an immunosuppressive signal and can prevent the hyperactivity of human immune system. Adenosine levels are significant decreased in serum from SLE patients. Adenosine level is regulated by the CD39, CD73 and adenosine deaminase (ADA). CD39/CD73/ADA catalyzed the cascade enzymatic reaction, which contained the adenosine generation and degradation. Adenosine affects the function of various immune cells via bind to the adenosine receptors, which are expressed on the cell surface. This review aims to export the changes of immune cells and adenosine signal pathway in SLE, as well as the effect of adenosine signal pathway in SLE development.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e29848