The Role of Exosomes in the Pathophysiology of Chronic Rhinosinusitis

Non-invasive biomarker analysis has made repetitive and painless sampling over time possible. Exosomes are being released from a parent cell and their cargo mirrors the cell micromilieu of the parent cell. Therefore, exosomes are promising surrogates for their parent cells. That is also why exosomes...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-01, Vol.11, p.812920-812920
Main Author: Mueller, Sarina K
Format: Article
Language:English
Subjects:
Cell Communication
Cellular and Infection Microbiology
Chronic Disease
chronic rhinosinusitis (CRS)
cystatin
exosome
Exosomes
Humans
Inflammation
pappalysin-1
Sinusitis - diagnosis
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Summary:Non-invasive biomarker analysis has made repetitive and painless sampling over time possible. Exosomes are being released from a parent cell and their cargo mirrors the cell micromilieu of the parent cell. Therefore, exosomes are promising surrogates for their parent cells. That is also why exosomes provide an improved signal-to-noise ratio. Current studies have identified valid non-invasive biomarkers that may be able to monitor disease severity. Exosomes are suggested to play an important role in interepithelial communication and are suggested to play a role in the initiation and maintenance of inflammation in CRS. They are, however, also involved simultaneously in several immunological processes including immune protection and immunosuppression. As the isolation of exosomes is time-consuming their value in everyday routine diagnostics has yet to be determined.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.812920