The mitochondrial DNA HVI and HVII sequences and haplogroup distribution in a population sample from Vietnam

Mitochondrial DNA (mtDNA) analysis has been used in forensics and requires well-established population databases for statistical interpretations. However, high-quality mtDNA data from Vietnamese population samples have been limited. To examine the mtDNA sequences and haplogroup compositions of a Vie...

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Bibliographic Details
Published in:Annals of human biology 2022-11, Vol.49 (7-8), p.367-371
Main Authors: Nguyen, Nam Ngoc, Hoang, Trong Luc, Nguyen, Trang Hong, Le, Phuong Thi, Nguyen, Chi Hung, Tran, Viet Vinh, Chu, Hoang Ha, Hoang, Ha
Format: Article
Language:English
Subjects:
Asia
DNA, Mitochondrial - genetics
Genetics, Population
haplogroups
Haplotypes
Humans
Mitochondrial DNA
Phylogeny
reference database
Sequence Analysis, DNA
Vietnam
Vietnamese population
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Summary:Mitochondrial DNA (mtDNA) analysis has been used in forensics and requires well-established population databases for statistical interpretations. However, high-quality mtDNA data from Vietnamese population samples have been limited. To examine the mtDNA sequences and haplogroup compositions of a Vietnamese population to provide an mtDNA dataset that can further be used to construct a Vietnamese-specific reference database. A total of 173 Vietnamese individuals were analysed for two hypervariable regions (HVI and HVII) of mtDNA. Forensic parameters were calculated and haplogroup assignment was performed based on the resulting mtDNA haplotypes. Genetic relationships between the Vietnamese and other Asian populations were investigated through principal component analysis (PCA) and pairwise F st . The Vietnamese population sample consisted of 145 different haplotypes with a random match probability of 0.96%, a power of discrimination of 0.9904, and a haplotype diversity of 0.9962. The samples were assigned to 83 haplogroups that were commonly reported in Asia. PCA and pairwise F st revealed close relationships of the Vietnamese population with other Asian populations, especially with populations in proximity. The results from this study can contribute to the current genetic information content as a supplementary mtDNA reference dataset for forensic investigations and phylogenetic research.
ISSN:0301-4460
1464-5033
DOI:10.1080/03014460.2022.2152488