Cholinergic stimulation with pyridostigmine reduces the QTc interval in coronary artery disease

Parasympathetic dysfunction is an independent risk factor in patients with coronary artery disease; thus, cholinergic stimulation is a potential therapeutic measure that may be protective by acting on ventricular repolarization. The purpose of the present study was to determine the effects of pyrido...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2002-06, Vol.35 (6), p.685-689
Main Authors: Castro, R R T, Porphirio, G, Serra, S M, Nóbrega, A C L
Format: Article
Language:English
Subjects:
Analysis of Variance
Anticholinesterase
BIOLOGY
Bradycardia - chemically induced
Cholinesterase Inhibitors - pharmacology
Coronary Disease - physiopathology
Cross-Over Studies
Double-Blind Method
Electrocardiography - drug effects
Heart Rate - drug effects
Humans
MEDICINE, RESEARCH & EXPERIMENTAL
Middle Aged
Pyridostigmine
Pyridostigmine Bromide - pharmacology
QTc interval
Stable angina
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Summary:Parasympathetic dysfunction is an independent risk factor in patients with coronary artery disease; thus, cholinergic stimulation is a potential therapeutic measure that may be protective by acting on ventricular repolarization. The purpose of the present study was to determine the effects of pyridostigmine bromide (PYR), a reversible anticholinesterase agent, on the electrocardiographic variables, particularly QTc interval, in patients with stable coronary artery disease. In a randomized double-blind crossover placebo-controlled study, simultaneous 12-lead electrocardiographic tracings were obtained at rest from 10 patients with exercise-induced myocardial ischemia before and 2 h after the oral administration of 45 mg PYR or placebo. PYR increased the RR intervals (pre: 921 +/- 27 ms vs post: 1127 +/- 37 ms; P
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/S0100-879X2002000600008