Bilateral subthalamic nucleus deep brain stimulation for refractory isolated cervical dystonia

Subthalamic nucleus (STN) deep brain stimulation (DBS) has been proven to be an alternative target choice for refractory isolated cervical dystonia (CD). However, assessments of its short and long-term safety, efficacy, and sustained effectiveness have been limited to few reports. Here, we evaluated...

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Bibliographic Details
Published in:Scientific reports 2022-05, Vol.12 (1), p.7678-7678, Article 7678
Main Authors: Yin, Feng, Zhao, Mingming, Yan, Xin, Li, Tong, Chen, Hui, Li, Jianguang, Cao, Shouming, Guo, Hui, Liu, Shuang
Format: Article
Language:English
Subjects:
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Adverse events
Deep brain stimulation
Dystonia
Electrical stimuli
Humanities and Social Sciences
multidisciplinary
Patients
Quality of life
Science
Science (multidisciplinary)
Solitary tract nucleus
Subthalamic nucleus
Torticollis
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Summary:Subthalamic nucleus (STN) deep brain stimulation (DBS) has been proven to be an alternative target choice for refractory isolated cervical dystonia (CD). However, assessments of its short and long-term safety, efficacy, and sustained effectiveness have been limited to few reports. Here, we evaluated nine consecutive refractory isolated CD patients who underwent bilateral STN DBS and accepted to short and long-term follow-up in this retrospective study. Seven time points were used to see the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores (pre-operation [baseline], 1, 3, 6, 12, 24 months post-operation and last follow-up) to assess improvement of dystonic symptoms. The 36-item Short-Form General Health Survey (SF-36) scores obtained at pre-operation and last follow-up to assess the changes in quality of life. All patients tolerated surgery well and acquired observable clinical benefits from STN DBS therapy. All patients achieved a considerable improvement in quality of life at the last follow-up. The hardware-related adverse events can be tolerated and the stimulation-related adverse events can be ameliorated by programming. Our data support the idea that bilateral STN DBS is a safety and effective method for the treatment of refractory isolated CD, with persistent and remarkable improvement in both movement and quality of life.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-11841-1