Assessing the reproducibility and predictive value of objective cough measurement for successful withdrawal of invasive ventilatory support in adult patients

Utilizing clinical tests, such as objective cough measurement, can assist in predicting the success of the weaning process in critically ill patients. A multicenter observational analytical study was conducted within a prospective cohort of patients recruited to participate in COBRE-US. We assessed...

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Bibliographic Details
Published in:BMC pulmonary medicine 2024-05, Vol.24 (1), p.218-218, Article 218
Main Authors: Varón-Vega, Fabio, Rincón, Adriana, Giraldo-Cadavid, Luis F, Tuta-Quintero, Eduardo, Palacios, Jonathan, Crevoisier, Stephanie, Duarte, Diana C, Poveda, Marcela, Cucunubo, Laura, Monedero, Pablo
Format: Article
Language:English
Subjects:
Adult
Aged
Agreements
Airway Extubation
Artificial respiration
Care and treatment
Collaboration
Cough
Critical Illness
Critically ill
Diagnosis
Disease
Extubation
Female
Heart rate
Humans
Intensive care
Male
Mechanical ventilation
Middle Aged
Mortality
Patient outcomes
Patients
Predictive Value of Tests
Prospective Studies
Reproducibility
Reproducibility of Results
Respiration, Artificial - methods
ROC Curve
Success
Ventilator Weaning - methods
Ventilators
Weaning
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Summary:Utilizing clinical tests, such as objective cough measurement, can assist in predicting the success of the weaning process in critically ill patients. A multicenter observational analytical study was conducted within a prospective cohort of patients recruited to participate in COBRE-US. We assessed the capability of objective cough measurement to predict the success of the spontaneous breathing trial (SBT) and extubation. Intra- and inter-observer reproducibility of the cough test and was evaluated using the intraclass correlation coefficient (ICC) and Cohen's weighted kappa. We used receiver operating characteristic curves (ROC-curve) to evaluate the predictive ability of objective cough measurement. We recruited 367 subjects who were receiving invasive mechanical ventilation. A total of 451 objective cough measurements and 456 SBTs were conducted. A significant association was found between objective cough measurement and successful SBT (OR: 1.68; 95% CI 1.48-1.90; p = 0.001). The predictive capability of the objective cough test for SBT success had a ROC-curve of 0.58 (95% CI: 0.56-0.61). Objective cough measurement to predict successful extubation had a ROC-curve of 0.61 (95% CI: 0.56-0.66). The intraobserver reproducibility exhibited an ICC of 0.94 (95% CI: 0.89-0.96; p 
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-024-03033-6